Detalles de la búsqueda
1.
Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11 C]PBR28 and Machine Learning Analysis.
Mov Disord;
37(1): 119-129, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34609758
2.
Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo.
Br J Anaesth;
126(1): 238-244, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33036760
3.
Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676.
J Pharmacol Exp Ther;
358(3): 464-71, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27402278
4.
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.
Brain;
138(Pt 9): 2687-700, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26137956
5.
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Clin Cancer Res;
30(7): 1338-1351, 2024 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37967136
6.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem;
67(4): 3090-3111, 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38306388
7.
Low background and high contrast PET imaging of amyloid-ß with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients.
Eur J Nucl Med Mol Imaging;
40(4): 580-93, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23324871
8.
Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study.
Clin Transl Sci;
16(6): 955-965, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36808835
9.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem;
66(13): 9147-9160, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37395055
10.
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹8F-PET imaging agents for ß-amyloid plaques.
Bioorg Med Chem Lett;
22(13): 4332-7, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22647721
11.
Synthesis and Preclinical Evaluation of [11C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor.
ACS Chem Neurosci;
13(14): 2078-2083, 2022 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35802379
12.
Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.
Neuro Oncol;
23(4): 687-696, 2021 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33123736
13.
Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.
Clin Cancer Res;
27(1): 189-201, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33028591
14.
Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.
J Neurochem;
114(3): 784-94, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20477945
15.
First Radiolabeling of a Ganglioside with a Positron Emitting Radionuclide: In Vivo PET Demonstrates Low Exposure of Radiofluorinated GM1 in Non-human Primate Brain.
ACS Chem Neurosci;
11(9): 1245-1249, 2020 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32324990
16.
Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake.
ACS Chem Neurosci;
11(12): 1756-1761, 2020 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32343551
17.
The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans.
Neuropharmacology;
162: 107809, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31589885
18.
A PET study in healthy subjects of brain exposure of 11C-labelled osimertinib - A drug intended for treatment of brain metastases in non-small cell lung cancer.
J Cereb Blood Flow Metab;
40(4): 799-807, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31006308
19.
Quantification and reliability of [11C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung - a test-retest PET study in control subjects.
EJNMMI Res;
10(1): 59, 2020 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32495011
20.
Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery.
Drug Discov Today;
24(5): 1067-1073, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30710641